APVV-19-0193 project (2020-2024): “New players in nanotherapy of neurodegenerative diseases: conditioned medium (KM) and extracellular vesicles (EV) of somatic stem cells”
The project addresses the highly actual topic of the mechanism by which somatic stem cells ensure the repair of damaged tissues by the following collaborators:
- cellular therapy: stem cell transplantation
- and cellular therapy: conditioned medium containing bioactive substances (trophic and growth factors, immunomodulators)
VEGA 1/0376/20 project (2020-2023) – “Secretome and extracellular vesicles of stem cells in relation to neuroregeneration and neuroplasticity”
The project deals with the standard production of secretome and extracellular vesicles of stem cells with anti-inflammatory and regenerative effects. It is necessary to prepare stimulated secretomes from stem cells of various origins, to test their neuroregenerative and neuroplastic effect on cell cultures (in vitro) and subsequently to select a selected group of patients with a spinal cord injury, which represents an important link to clinical practice (in vivo).
VEGA 1/0285/22 project (2022-2025) – “Canine neonatal tissues as an alternative source of mesenchymal stem cells in regenerative medicine”
The project is focused on the study of stem cells and their products isolated from promising sources such as neonatal tissues (amnion, placenta) considered biological waste in obstetric practice. The benefit of working with stem cells obtained from fetal tissues is their good availability and non-invasive collection. They are described as cells of a primitive nature, less immunogenic and compared to adult stem cells, they are not burdened by diseases developed during life. Our aim is to determine their potential in the therapy of neurodegenerative diseases where standard treatment fails.